Sociodemographic and clinical characteristics of 380 cases of odontogenic lesions in a Brazilian population

Noemi Martins Gomes da  Silva; Maria Vitória Zeno Passos da Silva; Guilherme Santos Vinhandelli; Danielle Resende Camisasca Barroso; Liliana Pimenta de Barros; Daniela Nascimento  Silva; Sérgio Lins de Azevedo Vaz; Águida Cristina Gomes Henriques

doi:10.5327/2525-5711.300

Authors

Noemi Martins Gomes da Silva Universidade Federal do Espírito Santo – Vitória (ES), Brazil. https://orcid.org/0000-0002-2828-6894
Maria Vitória Zeno Passos da Silva Universidade Federal do Espírito Santo – Vitória (ES), Brazil. https://orcid.org/0009-0007-1438-2117
Guilherme Santos Vinhandelli Universidade Federal do Espírito Santo – Vitória (ES), Brazil. https://orcid.org/0009-0000-1087-8165
Danielle Resende Camisasca Barroso Universidade Federal do Espírito Santo – Vitória (ES), Brazil. https://orcid.org/0000-0003-1193-2113
Liliana Pimenta de Barros Universidade Federal do Espírito Santo – Vitória (ES), Brazil. https://orcid.org/0000-0002-1649-3116
Daniela Nascimento Silva Universidade Federal do Espírito Santo – Vitória (ES), Brazil. https://orcid.org/0000-0003-2165-4989
Sérgio Lins de Azevedo Vaz Universidade Federal do Espírito Santo – Vitória (ES), Brazil. https://orcid.org/0000-0001-5578-5309
Águida Cristina Gomes Henriques Universidade Federal do Espírito Santo – Vitória (ES), Brazil. https://orcid.org/0000-0002-8591-3655

DOI:

https://doi.org/10.5327/2525-5711.300

Keywords:

Odontogenic Cyst, Odontogenic Tumor, Oral Pathology, Cross-Sectional Study

Abstract

Objective: Describe the sociodemographic and clinical characteristics related to odontogenic cysts and tumors in a population from the state of Espírito Santo, Brazil. Methods: All cases of odontogenic cysts and tumors diagnosed at the Oral Pathological Anatomy Service (SAP) of the Universidade Federal do Espírito Santo (UFES) between 2004 and 2022 were selected. The lesions were categorized according to the 2022 WHO classification. The frequency of cysts and tumors was calculated and the following information was collected: age, sex and skin color of the patients, presence of signs and symptoms, and specific lesion data such as radiographic appearance, location, size, association with unerupted teeth, tooth displacement and root resorption, whether the lesion corresponds to a recurrence, and treatment modality. Results: Cysts were more frequent than odontogenic tumors, especially radicular cysts. Ameloblastomas and cemento-ossifying fibroma were the most common odontogenic tumors. Conclusion: This study contributes to a better understanding and differentiation of odontogenic lesions, supporting dentists in the diagnostic process and treatment of these pathologies.

References

Philipsen HP, Reichart PA. The development and fate of epithelial residues after completion of the human odontogenesis with special reference to the origins of epithelial odontogenic neoplasms, hamartomas and cysts. Oral Biosci Med. 2004;1(3):171-9.

Bilodeau EA, Collins BM. Odontogenic cysts and neoplasms. Surg Pathol Clin. 2017;10(1):177-222. https://doi.org/10.1016/j.path.2016.10.006

World Health Organization. Classification of Tumours Editorial Board. Head and neck tumours. Lyon: International Agency for Research on Cancer; 2022.

Jaeger F, Noronha MS, Silva MLV, Amaral MBF, Grossmann SMC, Horta MCR, et al. Prevalence profile of odontogenic cysts and tumors on Brazilian sample after the reclassification of odontogenic keratocyst. J Craniomaxillofac Surg. 2017;45(2):267-70. https://doi.org/10.1016/j.jcms.2016.12.011

Silva K, Alves A, Correa M, Etges A, Vasconcelos AC, Gomes AP, et al. Retrospective analysis of jaw biopsies in young adults. A study of 1599 cases in Southern Brazil. Med Oral Patol Oral Cir Bucal. 2017;22(6):e702-e707. https://doi.org/10.4317/medoral.21918

Melo G, Batistella EA, Bett JVS, Grando LJ, Rivero ERC. Prevalence of oral and maxillofacial lesions in children and adolescents at a regional Brazilian oral pathology service: a retrospective study and the relevant literature review. Eur Arch Paediatr Dent. 2023;24(4):451-9. https://doi.org/10.1007/s40368-023-00800-7

Rioux-Forker D, Deziel AC, Williams LS, Muzaffar AR. Odontogenic cysts and tumors. Ann Plast Surg. 2019;82(4):469-77. https://doi.org/10.1097/SAP.0000000000001738

Ramakrishna Y, Verma D. Radicular cyst associated with a deciduous molar: a case report with unusual clinical presentation. J Indian Soc Pedod Prev Dent. 2006;24(3):158-60. https://doi.org/10.4103/0970-4388.27899

Manor R, Anavi Y, Kaplan I, Calderon S. Radiological features of glandular odontogenic cyst. Dentomaxillofac Radiol. 2003;32(2):73-9. https://doi.org/10.1259/dmfr/22912856

Stoelinga PJW. Keratocystic odontogenic tumour (KCOT) has again been renamed odontogenic keratocyst (OKC). Int J Oral Maxillofac Surg. 2019;48(3):415-6. https://doi.org/10.1016/j.ijom.2018.07.020

Jaafari-Ashkavandi Z, Akbari B. Clinicopathologic study of intra- osseous lesions of the jaws in Southern Iranian Population. J Dent (Shiraz). 2017;18(4):259-64. PMID: 29201968.

Franklin JRB, Vieira EL, Brito LNS, Castro JFL, Godoy GP. Epidemiological evaluation of jaw cysts according to the new WHO classification: a 30-year retrospective analysis. Braz Oral Res. 2021;35:e129. https://doi.org/10.1590/1807-3107bor-2021.vol35.0129

Kammer PV, Mello FW, Rivero ERC. Comparative analysis between developmental and inflammatory odontogenic cysts: retrospective study and literature review. Oral Maxillofac Surg. 2020;24(1):73-84. https://doi.org/10.1007/s10006-019-00816-8

de Medeiros W, da Silva L, Santos PPA, Pinto LP, de Souza LB. Clinicopathological analysis of odontogenic tumors over 22 years period: experience of a single center in northeastern Brazil. Med Oral Patol Oral Cir Bucal. 2018; 23(6):e664-e671. https://doi.org/10.4317/medoral.22618

El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO classification of head and neck tumours. 4th ed. Geneva: World Health Organization; 2017.

Du C, Wang Z, Lan D, Zhu R, Wang D, Wang H, et al. Clinical analysis of 1,038 cases of odontogenic jawbone cysts. BMC Oral Health. 2024;24(1):1387. https://doi.org/10.1186/s12903-024-05167-9

Sullivan M, Gallagher G, Noonan V. The root of the problem: occurrence of typical and atypical periapical pathoses. J Am Dent Assoc. 2016;147(8):646-9. https://doi.org/10.1016/j.adaj.2016.02.018

Costa FWG, Viana TSAV, Cavalcante GM, Silva PGB, Cavalcante RB, Nogueira AS, et al. A clinicoradiographic and pathological study of pericoronal follicles associated to mandibular third molars. J Craniofac Surg. 2014;25(3):e283-7. https://doi.org/10.1097/SCS.0000000000000712

Shin SM, Choi EJ, Moon SY. Prevalence of pathologies related to impacted mandibular third molars. Springerplus. 2016;5(1):915. https://doi.org/10.1186/s40064-016-2640-4

Santana DCP, Couto LA, Passos-Soares JS, Xavier CDA, Mesquita RA, Felix FA, et al. Sociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a Brazilian multicenter study. Clin Oral Invest. 2023;27(11):6951-9. https://doi.org/10.1007/s00784-023-05313-7

Brannon RB. The odontogenic keratocyst. A clinicopathologic study of 312 cases. Part I: Clinical features. Oral Surg Oral Med Oral Pathol. 1976;42(1):54-72. https://doi.org/10.1016/0030-4220(76)90031-1

Costa DOP, Mauricio AS, Faria PAS, Silva LE, Mosqueda-Taylor A, Lourenco SQC. Odontogenic tumors: a retrospective study of four Brazilian diagnostic pathology centers. Med Oral Patol Oral Cir Bucal. 2012;17(3):e389-94. https://doi.org/10.4317/medoral.17630

Santos TS, Piva MR, Andrade ESS, Vajgel A, Vasconcelos RJH, Martins-Filho PRS. Ameloblastoma in the Northeast region of Brazil: a review of 112 cases. J Oral Maxillofac Pathol. 2014;18(1):66-71. https://doi.org/10.4103/0973-029X.141368

Hendra FN, Kalla DSN, Van Cann EM, de Vet HCW, Helder MN, Forouzanfar T. Radical vs conservative treatment of intraosseous ameloblastoma: systematic review and meta‐analysis. Oral Dis. 2019;25(7):1683-96. https://doi.org/10.1111/odi.13014

Escobar E, Gómez-Valenzuela F, Peñafiel C, Ortega-Pinto A. Odontogenic tumours in a Chilean population: a retrospective study of 544 cases based on 2022 WHO classification. Med Oral Patol Oral Cir Bucal. 2023;28(6):e596-e606. https://doi.org/10.4317/medoral.26008

Ramos GO, Porto JC, Vieira DSC, Siqueira FM, Rivero ERC. Odontogenic tumors: a 14-year retrospective study in Santa Catarina, Brazil. Braz Oral Res. 2014;28:33-8. https://doi.org/10.1590/S1806-83242013005000030

Nguyen DK, Van Huynh D. Clinical and radiological characteristics of odontomas: a retrospective study of 90 cases. Imaging Sci Dent. 2023;53(2):117-26. https://doi.org/10.5624/isd.20220184

DeColibus KA, Rasner DS, Okhuaihesuyi O, Owosho AA. Clinicoradiopathologic analysis of odontomas: a retrospective study of 242 cases. Dent J. 2023;11(11):253. https://doi.org/10.3390/dj11110253

Manfredini M, Ferrario S, Creminelli L, Kuhn E, Poli PP. Compound odontoma associated with dentigerous cyst incidentally detected in an adult patient: tomography and histological features. Case Rep Dent. 2022;2022:6210289. https://doi.org/10.1155/2022/6210289

Pontes FSC, Mosqueda-Taylor A, Souza LL, Paula LP, Batista LAL, Rodrigues-Fernandes CI, et al. Hybrid odontogenic lesions: a systematic review of 203 cases reported in the literature. J Oral Pathol Med. 2022;51(1):5-12. https://doi.org/10.1111/jop.13238

Akshatha BK, Manjunath GS, Soundarya N. Calcifying odontogenic cyst associated with compound odontoma – a rare entity. J Oral Maxillofac Pathol. 2023;27(Suppl 1):S69-S74. https://doi.org/10.4103/jomfp.jomfp_411_22

Pimenta JR, Zuccherato LW, Debes AA, Maselli L, Soares RP, Moura-Neto RS, et al. Color and genomic ancestry in Brazilians: a study with forensic microsatellites. Hum Hered. 2006;62(4):190-5. https://doi.org/10.1159/000096872

Rees V, Klare M, Samaniego V, Leiva F, Jarra R, Rondanelli BM, et al. Epidemiological features of 4777 cysts and odontogenic tumors based on the 2022 WHO Classification. Oral Dis. 2024. Online ahead of print. https://doi.org/10.1111/odi.15146