Secretory carcinoma of the parotid gland in a pediatric patient: an unusual report and literature update

Tayná Figueiredo Maciel; Sílvia Cristina Oliveira Brandão; Maiko Ramos Maia; Jeconias Câmara; Tatiana Nayara Libório-Kimura; Renata Gualberto da Cunha

doi:10.5327/2525-5711.313

Authors

Tayná Figueiredo Maciel State University of Campinas, Piracicaba Dental School, Oral Diagnosis Department – Piracicaba (SP), Brazil. https://orcid.org/0000-0003-1328-2468
Sílvia Cristina Oliveira Brandão Amazonas State Oncology Control Center Foundation, Pathology Laboratory – Manaus (AM), Brazil. https://orcid.org/0009-0004-7395-5067
Maiko Ramos Maia Amazonas State Oncology Control Center Foundation, Pathology Laboratory – Manaus (AM), Brazil. https://orcid.org/0000-0003-3512-4065
Jeconias Câmara Federal University of Amazonas, School of Medicine, Department of Legal Medicine and Pathology – Manaus (AM), Brazil. https://orcid.org/0000-0001-7260-0900
Tatiana Nayara Libório-Kimura Federal University of Amazonas, School of Medicine, Department of Legal Medicine and Pathology – Manaus (AM), Brazil. https://orcid.org/0000-0001-7800-8326
Renata Gualberto da Cunha Federal University of Amazonas, School of Medicine, Department of Legal Medicine and Pathology – Manaus (AM), Brazil. https://orcid.org/0000-0003-2730-9932

DOI:

https://doi.org/10.5327/2525-5711.313

Keywords:

Secretory carcinoma, MASC, Salivary glands, Diagnosis, Case report

Abstract

A 16-year-old male patient exhibited a nodular lesion measuring 5.0 centimeters in its greatest diameter in the right parotid gland. This lesion had been present for a period of two years, without any associated symptoms. Upon palpation, the lesion was characterized as demarcated, firm, and painless. The patient underwent surgical excision, and the initial hypothesis was that the lesion was a pleomorphic adenoma (PA). Microscopically, the tumor exhibited a variable growth pattern between cribriform and micropapillary areas, with neoplastic cells positive for mammaglobin, S-100, and Pan-Trk. Immunohistochemistry was employed to substantiate the diagnosis of secretory carcinoma (SC). Two years following the surgical intervention, no signs of recurrence or complications have been observed. Although rare, secretory carcinoma (SC) in pediatric patients has been documented in the literature and can mimic benign neoplasms due to its mild characteristics.

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