Extranodal T/NK cells lymphoma presenting as persistent facial swelling: case report

Autores

  • Laryssa Queiroz Cunha State University of Campinas, Piracicaba Dental School, Stomatology and Oral Pathology Areas, Department of Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0003-1357-4129
  • Alexandre Bellotti Hospital Estadual de Urgências da Governador Otávio Lage de Siqueira, Department of Oral and Maxillofacial Surgery and Traumatology, Maxillofacial Surgeon – Goiânia (GO), Brazil. https://orcid.org/0000-0002-6621-6491
  • Hélen Kaline Farias Bezerra State University of Campinas, Piracicaba Dental School, Stomatology and Oral Pathology Areas, Department of Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0002-5236-8988
  • Lucas Lacerda de Souza State University of Campinas, Piracicaba Dental School, Stomatology and Oral Pathology Areas, Department of Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0002-9481-7796
  • Ivan José Correia-Neto State University of Campinas, Piracicaba Dental School, Stomatology and Oral Pathology Areas, Department of Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0009-0007-3828-0107
  • Pablo Agustin Vargas State University of Campinas, Piracicaba Dental School, Stomatology and Oral Pathology Areas, Department of Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0003-1840-4911
  • Márcio Ajudarte Lopes State University of Campinas, Piracicaba Dental School, Stomatology and Oral Pathology Areas, Department of Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0001-6677-0065
  • Henrique Moura de Paula CAPC Laboratory, Pathologist, Department of Pathology – Goiânia (GO), Brazil. https://orcid.org/0000-0003-3232-2234
  • Yana De Sousa Rabelo Clinical Hospital of the Federal University of Goiânia, Department of Hematology –Goiânia (GO), Brazil.
  • Eduardo Zancopé Federal University of Uberlândia, School of Dentistry, Fixed Prosthesis and Dental Materials, Department of Occlusion – Uberlândia (MG), Brazil. https://orcid.org/0000-0002-6567-4810

DOI:

https://doi.org/10.5327/2525-5711.407

Palavras-chave:

Lymphoma, Non-Hodgkin, Extranodal NK-T-Cell

Resumo

Extranodal NK/T-cell lymphoma (ENKTL) is a histopathological subtype of non-Hodgkin’s lymphoma strongly associated with Epstein-Barr virus (EBV) infection. This malignancy is characterized by extensive necrosis, often resulting in severe tissue destruction and midfacial deformities. The present study aims to report a case of ENKTL in which the primary clinical manifestation was persistent, painless facial edema, notably without necrotic features. The patient underwent combined therapy with DeVIC chemotherapy and radiotherapy, demonstrating a favorable tumor response with no evidence of recurrence after a nine-month follow-up period. Accurate and timely diagnosis of ENKTL is critical for optimizing patient outcomes, mitigating tissue destruction, and reducing both morbidity and mortality. Therefore, ENKTL should be considered as a differential diagnosis in cases of unexplained diffuse facial swelling. Additionally, a comprehensive literature review was conducted to examine previously reported cases of ENKTL presenting with facial swelling.

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Publicado

2026-04-08

Como Citar

1.
Cunha LQ, Bellotti A, Bezerra HKF, Souza LL de, Correia-Neto IJ, Vargas PA, et al. Extranodal T/NK cells lymphoma presenting as persistent facial swelling: case report. J Oral Diagn [Internet]. 8º de abril de 2026 [citado 17º de abril de 2026];11. Disponível em: https://www.joraldiagnosis.com/revista/article/view/407

Edição

v. 11 (2026)

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Copyright (c) 2026 Laryssa Queiroz Cunha, Alexandre Bellotti , Hélen Kaline Farias Bezerra, Lucas Lacerda de Souza, Ivan José Correia-Neto, Pablo Agustin Vargas, Márcio Ajudarte Lopes, Henrique Moura de Paula, Yana De Sousa Rabelo, Eduardo Zancopé

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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.